Certain Immune Reactions To Viruses May Be Responsible For Learning Problems- Research.

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“Researchers have discovered a mechanism by which the body’s immune reaction to viruses like influenza and HIV may cause learning and memory problems.

This is the finding of a study led by researchers from NYU
Langone Medical Center and published online May 15 in Nature Medicine. Evidence in mice suggests that the entry of a virus anywhere in the bloodstream turns
on “first responder”
immune cells called
CX3CR1highLY6Clow
monocytes, which then release the
inflammatory signaling protein TNF-α.

According to the authors of the study, TNF-α then travels to the brain where it blocks the formation of nerve cell connections needed to
turn sensory information into
memories. Although immune system activation by
viruses has long been
linked to cognitive
problems, the underlying mechanisms have been poorly understood. In the new report, researchers found that virus-associated immune activation causes a loss of connections between
nerve cells within brain circuits in the cortex, the brain region responsible
for learning.

Such mice then do worse on established tests of learning ability. The observed changes in nerve connections were
triggered, not in the
brain, but out in the
body (the periphery)
where viral infection
first makes contact with CX3CR1highLY6Clow
monocytes in the
bloodstream, say the
authors.”

READ FULL CONTENT at https://www.sciencedaily.com/releases/2017/05/170515134122.htm/

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